Introduction: Placental SITE trophoblastic tumor (PSTT) is a subgroup of gestational trophoblastic tumor and its incidence is very RARE and 1 in 10000. The origin of this tumor is placental SITE and its symptoms are vaginal bleeding, metastatic symptoms, and …. Here, a RARE presentation of PSTT is reported.Case Report: A 24-years old woman, P1L1 with history of vaginal delivery one year ago and abnormal vaginal bleeding from 6 months ago had referred. Pelvic sonography reported a fibroma sized 29×45 mm as a myoma in the uterus. Due to abnormal vaginal bleeding which was refractory to medical therapy, myomectomy was done. The pathologic diagnosis was leiomyosarcoma. Then, the patient was referred to Ghaem Hospital Tumor Clinic. The diagnosis of the second pathology review of the same specimen was placental SITE trophoblastic tumor. Serum hCG level was 119 milliunit in milliliter. The patient had no desire to preserve fertility, so hysterectomy was done. One week after surgery, hCG level was normal and now after 8 months, the patient is disease free.Conclusion: Placental SITE trophoblastic tumor is a RARE tumor which should be suspected in a patient who presents with term pregnancy and abnormal vaginal bleeding and a myoma in sonography.

Archaeobotany is one of the interdisciplinary sciences in archaeology. Archaeobotany studies plant remains in archaeological contexts. Based on plant findings, it discusses topics such as people's livelihood, agriculture, vegetation, climate changes, dating, etc. So, this course can reply to many questions archaeologists face about an ancient SITE and people. In recent years, archaeologists have paid a lot of attention to this field and tried to use experts in excavations. One of the excavations that has paid a lot of attention to archaeobotany, is Feyzabad SITE. This SITE has Islamic periods. During the excavation in 2022 in this SITE, some ovens were found, as well as some samples from them. In this research, we intend to answer questions such as the functioning of the sampled ovens and the identification of plant remains in the ovens. Finally, by combining the information found, we will shed light on the lives of the people of this period. By doing this research, our information about the life of the people belonging to this area, their livelihood and the common types of plant remains used in this area will increase. Also, micro information about climatic conditions will be obtained. After carrying out the necessary investigations and research, it was found that the ovens found in the trench D8 are related to cooking to the inner part of the royal citadel. Besides the more specialized work that is being done, animal husbandry and agriculture are popular. Some climate changes such as warmer weather and less humidity were also identified

In the majority of patients undergoing transcatheter aortic valve implantation, the transfemoral access is the suggested approach due to its less invasive nature and feasibility in patients with suitable vascular anatomy. The complications of the transfemoral access SITE are generally vascular; however, we herein present a RARE case of colon perforation following the transfemoral procedure owing to prior abdominal surgery. A transfemoral aortic valve was inserted on account of severe aortic stenosis and a high probability of surgical mortality. The patient developed acute abdomen following the procedure. Hemicolectomy was performed because of colonic perforation caused by femoral catheterization. The patient was well at 3 months’ follow-up.

Background: Surgical scar endometriosis is typically presented as a slow-growing, painful abdominal mass near the SITE of a past surgery. Endometriosis on the trocar port SITE is RARE. To best of our knowledge, only 17 cases have been reported in the literature. The nonspecific nature of endometriosis presents a diagnostic challenge, and it is often considered as an incisional hernia or other conditions. Case: Here, we described our experience with a recurrent abdominal scar endometriosis case at the trocar port SITE of a previous laparoscopy, which was initially thought to be an incisional hernia. Conclusion: Abdominal wall endometriosis should be considered as an important differential diagnosis in females with a positive history of prior abdominal surgery, presented with painful nodule or mass at the SITE of the surgery.

Malacoplakia is a RARE chronic inflammatory disease associated with infection and immunosuppression, and very few occurrences have been reported in the bone. The authors describe the case of a 22-year-old woman with paraplegia and urinary and fecal incontinence whose thoracic spine Magnetic Resonance Imaging suggested a tumoral or extensive inflammatory process in the body of the 8th, 9th and 10th thoracic vertebrae. On histology, however, the area turned out to be malacoplakia of bone. Although microbiologic cultures and polymerase chain reaction were negative for Mycobacterium tuberculosis, the lesion demonstrated regression following treatment with anti-TB regimen which had been started because of clinical suspicion.

Primary core of Germi has been developed on the relative flat topographic space, but due to the land limitations, these days, this town is frequently (over 70%) developing in the high steep slopes (8 to 30 degrees). Active faults of the region and the presence of unresisting superficial and deposits and geological formations have caused instability of the urban constructions formation especially in the east and north east of this small city. In addition, the subsidence phenomena and cracks in foundations, due to deposit silts with the high percentage of clay and with high shear steers, have seriously threatened urban constructions. The large land slide in the 1995 destroyed some about the 250 residuals, hospitals and schools in the eastern slope of the town in the Katol district which led to obligatory replacing of some residuals. According to the research findings, out of whole urban land use (449.4 ha), 145.5 of them (32.4%) is located in the unsuitable to completely high risk zones. Therefore, occurrence of any earthquake stronger than 5.5 with Richter Scale, landslides, subsidence phenomena, subsidence liquefactions, and environmental hazards of geomorphic phenomena, result in crakes, movement and instability of soil formation, and the destruction of the constructions in the slopes.

The bioluminescence process is a widespread phenomenon in nature. The luciferase enzymes are identified in some domains of life, but the luciferases from the Lampyridae family are considered for biological applications. The molecular cloning of a new type of Iranian firefly luciferase from Lampyroidea maculata was reported, previously. In this study, the RARE codons of the Iranian insect luciferase gene were analyzed using the computational databases as ATGme, RACC, LaTcOm, and Sherlocc. Also, the structural modeling process of this enzyme was performed. Next, the status of these RARE codons in this structural model was evaluatedusing SPDBV 4. 10 and PyMOL 2. 3. 2 software. In the following, the substrate binding SITE in the enzyme's active SITE was studied using the AutoDock Vina 1. 5. 4. By molecular modeling, some RARE codons were identified that may have a critical role in the structure and function of this luciferase. AutoDock Vina was used in the molecular docking that recognizes Asp531 that yield closely related to luciferin and AMP binding SITE. These bioinformatics analyzes play an important role in the design of new drugs.

Most organizations in urban and urban structures in Ardabil embark on authority project planning and land use almost without scientific consideration of environmental potential, which does not conform to urban sustainable development. According to the soils physical analysis results, Liquid Limit and Plasticity Index of central and eastern part of the city are high. Also, due to the granolometric results of soil formation, there are high percentages of Clay, silt in the unresisting Quaternary alluvial and marl formation in the urban SITE. Therefore, high extension sensitive soil, silt and marl, gel fraction, capillarity frost heaving in some regions of Ardabil cause land subsidence, emergence of Creek, fussier and titling the structures walls and foundations and caused to intensive distraction of streets Asphalt. On the other hand, steepness of geology layers and topographic, influence of Neo-tectonic, and active micro faults, in the western parts of the city (Carshnasan and Cosar and Dadgostary) make the region a potentially high risk area. It is suggested, that urban sustainable planning must be undertaken with systematic study of SITE Geology, hydro-geomorphology and a prediction of probable problems.

Background: Pathogenic variants of RUNX2, a gene that encodes an osteoblast-specific transcription factor, have been shown as the cause of CCD, which is a RARE hereditary skeletal and dental disorder with dominant mode of inheritance and a broad range of clinical variability. Due to the relative lack of clinical complications resulting in CCD, the medical diagnosis of this disorder is challenging, which leaves it underdiagnosed. Methods: In this study, nine healthy and affected members of an Iranian family were investigated. PCR and sequencing of all exons and exon-intron boundaries of RUNX2 (NM_001024630) gene was performed on proband. Co-segregation analysis was conducted in the other family members for the identified variant. Additionally, a cohort of 100 Iranian ethnicity-matched healthy controls was screened by ARMS-PCR method. Results: The novel splice SITE variant (c. 860-2A>G), which was identified in the intron 6 of RUNX2 gene, co-segregated with the disease in the family, and it was absent in healthy controls. Pathogenicity of this variant was determined by several software, including HSF, which predicts the formation or disruption of splice donor SITEs, splice acceptor SITEs, exonic splicing silencer SITEs, and exonic splicing enhancer SITEs. In silico analysis predicted this novel variant to be disease causing. Conclusion: The identified variant is predicted to have an effect on splicing, which leads to exon skipping and producing a truncated protein via introducing a premature stop codon.